The feeling of insects crawling on the calves is clinically known as ant walking sensation. The ant walking sensation may be caused by non-disease factors, such as poor blood circulation, etc., but it may also be caused by disease factors, such as diabetic peripheral neuropathy and restless leg syndrome. 1. Non-disease factors: Prolonged squatting will lead to local blood circulation obstruction, and after changing the posture, the blood circulation in the lower limbs will be restored again, thus causing an ant walking sensation in the calves, which will disappear soon under normal circumstances and is not accompanied by other discomforts. 2. Disease factors (1) Diabetic peripheral neuropathy: It is one of the complications of diabetes mellitus, in which the distal part of the limbs (such as calves, etc.) will have symmetric numbness, ankylosis and other abnormal sensations, accompanied by muscular weakness, muscle atrophy and other manifestations. (2) Restless Legs Syndrome: The cause of the disease is still unclear, and it is mostly related to factors such as heredity and abnormal dopamine function in the brain. Patients can have indescribable discomfort in both lower limbs at rest or at night during sleep, such as numbness, ants, electric shock, etc. Generally, after activity, the symptoms can be alleviated, but after stopping, the symptoms will reappear. In addition, there are many other causes that can cause worms crawling on the lower legs. It is recommended that patients seek medical attention in time to rule out non-disease factors and then undergo treatment at the earliest possible time.