The presence of overlapping infection of HCV and HBV affects the prognosis of liver disease HCV infection in patients with chronic liver disease, especially dual infection of HBV and HCV, may accelerate the progression of liver disease. Viral hepatitis (viralhepatitis) is a group of infectious diseases caused by a variety of different hepatitis viruses, mainly liver damage, according to the pathogenic diagnosis, there are at least five types of hepatitis viruses, namely hepatitis A, B, C, D and E viruses, which cause viral hepatitis A, B, C, D and E, respectively, namely hepatitis A (hepatitis A), hepatitis B ( hepatitis B), hepatitis C), hepatitis D) and hepatitis E). Another type of viral hepatitis called hepatitis G is less common. what are the tests for the presence of overlapping infection between HCV and HBV? The HCV genome is a long open reading frame (ORF) with non-coding regions on both sides of the 5′ and 3′, starting from the 5′ end, the coding region consists of seven gene regions, namely C, E1, E2, NS1, NS2,NS3, NS4 and NS5. NS5, with the C region encoding the nucleocapsid protein and the E1 and E2/NS1 regions encoding the envelope protein. NS2 to NS5 encode non-structural proteins, some of which are not well understood. NS3 encodes helicase and protease, and the NS3 protein is highly antigenic and produces antibodies of diagnostic value. NS5 encodes an RNA-dependent RNA polymutase, and antibody positivity to NS5 protein appears to be related to viral activity. laboratory testing for HCV can be performed by PCR to detect viral RNA, and also to detect antibodies. 2. Ultrasound for liver disease Ultrasound is a medical test that patients are often exposed to during their visits. Ultrasound of the liver is helpful in helping to diagnose liver disease. Indications liver cysts, polycystic liver, liver abscess, hepatic hemangioma, splenomegaly, fatty liver, bruised liver, etc.