Osteoarthritis (OA) is a chronic joint disease in which the main changes are degeneration and destruction of the articular cartilage surfaces and secondary osteophytes. The main manifestations are joint pain and immobility, narrowing of the joint space, dense subchondral bone, broken trabeculae, sclerosis and cystic changes on x-ray. There is lip-like hyperplasia at the edge of the joint. In the later stage, the bone ends are deformed and the joint surface is uneven. The cartilage in the joint peels off and the bone fragments into the joint, forming an intra-articular free body. Osteoarthritis is also known as proliferative arthritis, degenerative arthritis and osteoarthropathy of the knee. Osteoarthritis is primarily a degenerative disease that involves premature aging of the joints, especially of the articular cartilage. Articular cartilage is inherent and consists of a special dense connective tissue, including chondrocytes, collagen fibers, and a gel-like matrix. The gel-like matrix consists of chondroitin sulfate, keratin sulfate, glycoprotein, salt, and water; the collagen fibers are normally arranged in three layers, with the surface layer consisting of the middle section of the collagen fibers, which is closely aligned, parallel to the surface, smooth, and flat, and this layer is about 10% of the full thickness and provides a suitable weight-bearing surface. The collagen fibers in the middle layer are arranged in a tangential direction, and this layer is about 30% of the full layer thickness. The underlying fibers are vertically aligned and cover approximately 60% of the full thickness. Under pressure on the joint, the cartilage compresses and stretches, producing a cushioning effect to disperse the pressure and protect the subchondral bone from damage. The collagen fibers in cartilage are elastic and can quickly return to their original shape. Therefore, the elastic effect of collagen fibers is stronger in youth or under intermittent pressure, and the cushioning effect is also good. However, in old age or under continuous compression, the elasticity decreases, the ability to extend is diminished, and the recovery time is prolonged. The result of long-term use of the joint is cartilage wear, coupled with osteoporosis in the elderly, the support of the subchondral bone to it decreases, eventually leading to cartilage peeling off and falling off. Once cartilage is stripped, it cannot be regenerated. The result of cartilage degeneration and exfoliation is that the bone ends are exposed and the joint surface is transformed from a smooth surface of super ice to a “firebrick surface”. The result of joint movement is a large amount of bone microdebris, which leads to aseptic inflammation in the joint, recurrent pain, fluid accumulation, swelling, synovial hyperplasia, and osteophytes. Osteoarthritis represents the aging of the joints and is therefore called senile arthritis. Whenever it is cloudy or rainy or the climate turns cold, many patients often have increased knee pain, and these patients are mostly middle-aged and elderly, more women than men, so it is also called “old cold leg”. Chronic pain is currently plaguing many middle-aged and elderly people, and osteoarthritis is one of the main causes of chronic pain in the elderly. Statistics show that 24% of the population suffers from moderate to severe pain most of the time. It has been estimated that there are 75 million pain sufferers in the United States, 1 in 6 of whom have pain due to arthritis. Chronic pain is a disease in itself, and the latest scientific research has found that chronic pain can make people dozens of years older than their peers. Those in their 50s with chronic pain have the same physical strength as older people in their 80s without pain, which means that chronic pain makes people almost 30 years older.