Monoclonal hyperplasia of b cells refers to monoclonal B lymphocytosis. Monoclonal B-lymphocytosis is divided into three types based on immune manifestations, including non-chronic lymphocytic leukemia, atypical chronic lymphocytic leukemia, and chronic lymphocytic leukemia. The diagnostic criteria are abnormal B-cell clones, peripheral blood B lymphocytes less than 5 × 10⁹/L, enlarged liver and spleen lymph nodes, absence of anemia and thrombocytopenia, and absence of other clinical symptoms of chronic lymphoproliferative disease. If these diagnostic criteria are met the diagnosis of B-cell monoclonal hyperplasia is confirmed. The patient will undergo laboratory tests, imaging tests, tumor markers, and other relevant tests. Patients with monoclonal B lymphoproliferative disorder should actively seek medical treatment, and patients should not treat themselves to avoid delaying their condition.