Double deficiency of yin and yang generally refers to a deficiency of both yin and yang, and taking Zhi Bai Di Huang Wan alone usually fails to achieve the therapeutic goal. Zhi Bai Di Huang Wan consists of Radix Rehmanniae Praeparata, Cornu Cervi Pantotrichum, Rhizoma Dioscoreae, Rhizoma Dioscoreae, Poria, and Zedoaria. It can nourish yin and lower fire (nourish yin essence and lower fire). It is used in treating yin deficiency and fire (deficiency of yin essence in the body, resulting in hyperactive fire), hot flashes (a burst of fever), night sweating (abnormal sweating after going to sleep, sweating stops after waking up), dry mouth and sore throat, tinnitus, spermatorrhea, and short and reddish urination (small amount of urination, dark yellow in color). Avoid indigestible food. Not suitable for patients with cold and fever. It is forbidden for those who are allergic to this product, and people with allergies should be cautious in using it. Yin and yang deficiencies are often seen when the disease develops to a serious stage where both yin and yang deficiencies occur simultaneously. Treatment should be based on both yin and yang, or according to yin and yang deficiencies, there is a preference for the primary and secondary treatment. For example, Zhi Bai Di Huang Wan with Lock Yang Jie Jing Wan has the effect of warming the kidneys and fixing the essence, and is used for soreness and weakness of the waist and knees (a feeling of soreness and weakness of the waist and knees), dizziness, tinnitus, spermatorrhea and premature ejaculation due to deficiency of kidney yang (lack of yang qi in the kidneys) (lack of yang qi in the kidneys). To sum up, it is difficult to treat yin and yang deficiency by taking Zhi Bai Di Huang Wan alone. It is recommended that patients should consult a doctor in time for Chinese medicine diagnosis and then take it together with suitable medicines by a physician.