The significance of renal puncture biopsy is as follows: 1. Renal puncture biopsy can guide treatment, because the prerequisite for effective treatment of the disease is correct diagnosis, and its therapeutic significance is not different due to different pathological changes in patients, such as sometimes hormone shock is needed, sometimes combined with cytotoxic drugs, etc.; 2. Renal puncture biopsy can determine the prognosis, if the patient has a good prognosis, their psychological burden can be reduced, in the case of poor prognosis, the patient can be informed in advance to make the corresponding preparations, and the trend of the patient’s kidney lesion progression can be clarified; 3. Renal puncture biopsy can enrich the clinical diagnosis of kidney disease and guide the development of clinical kidney disease.