Symptoms of bile reflux vary according to the number of refluxes and the amount of reflux. Occasional bile reflux with a small amount of reflux usually has no obvious clinical symptoms; if the reflux episodes are frequent and the amount of reflux is large, persistent burning pain in the upper and middle abdomen and vomiting are often seen. Bile reflux is generally mixed with bile duodenal fluid reflux, such as in the fasting or postprandial occasional bile reflux, reflux flow is small, gastric emptying is normal, generally has no effect on the human body. However, if the episodes are frequent, the reflux flow is large and lasts for a long time, the following symptoms can occur: most of them can be manifested as persistent burning pain in the middle and upper abdomen, and the pain is aggravated after meals, which cannot be relieved by taking alkaline drugs. A few patients may present with retrosternal burning pain, which is associated with reflux esophagitis. In addition, bilious vomiting is its characteristic manifestation. Due to the obstacle of gastric emptying, the vomiting occurs mostly at night, and the vomit is accompanied by food, and occasionally there may be a small amount of blood. Because of the fear that eating will aggravate the symptoms, the patient often reduces the amount of food, and anemia, emaciation and malnutrition may occur. If the above symptoms occur, it is recommended to consult a doctor to find out the cause.