Pain in the middle of the left rib cage is seen in three cases: the first case is seen in elderly patients with a history of coronary heart disease, who experience pain in the middle of the left rib cage during an angina attack, accompanied by chest tightness, shortness of breath, panic, dizziness, and weakness, usually under the stimulation of triggers such as exertion, satiety, or mood swings. At this time, patients can be advised to take sublingual nitroglycerin to dilate the coronary arteries to relieve the symptoms. The second condition is seen in patients with cardiovascular neuropathy, which is common in young people without a previous diagnosis of coronary artery disease, who often experience pain in the middle of the left rib cage for a longer period of time, mainly stabbing pain, and subjective symptoms that are not relieved by rest or medication. The third condition, seen in patients with intercostal neuralgia, is a longer duration of pain, which is aggravated by pressure on the painful area, and is mainly treated locally.