Shifted diverticula of duodenal segments 2 and 3 can be treated conservatively and surgically depending on the condition to improve the disease. 1. Conservative treatment: The treatment of diverticular disease is individualized according to the severity of the disease. The presence of diverticula is not an indication for drug therapy, as most patients do not progress to symptomatic disease. If the patient is not clinically unwell, conservative treatment is given for observation. Diet should be light, moderate amount of vitamin-rich food, reduce the digestive burden of the gastrointestinal tract, avoid spicy stimulation, cold food, avoid smoking and alcohol. 2. Drug therapy: when diverticulum has abdominal pain, abdominal distension, as well as changes in bowel habits, quality of life is significantly impaired, medication is needed to get better. This includes the use of dietary fiber alone or in combination, antibiotics such as rifaximin, the anti-inflammatory drug mesalazine and probiotics. 3. Surgery: If the patient’s intestines show symptoms such as bleeding or perforation, or if the diverticulum causes pancreatitis or biliary tract infection, the diverticulum can be removed surgically to improve the condition. Patients should actively cooperate with doctors to carry out appropriate treatment, standardize the use of medication under the guidance of doctors, and go to the hospital for regular review.