The sudden absence of menstruation at the age of 50 may be due to menopause, or it may be caused by polycystic ovary syndrome, hypothyroidism and other diseases. 1. Menopause: the ovarian function of women at the age of 50 is gradually declining, and once the phenomenon of ovarian failure occurs, they will enter a permanent state of no menstruation, and the symptom of sudden absence of menstruation occurs. 2. Polycystic Ovary Syndrome: Polycystic Ovary Syndrome may be the result of the combined effects of genetics, metabolism, and the environment, and may lead to amenorrhea due to the excessive secretion of androgens of adrenal origin, resulting in a sudden absence of menstruation at the age of 50. 3. Hypothyroidism: Hypothyroidism is a systemic disease, mainly caused by insufficient secretion of thyroid hormones in the body, which may be related to autoimmune diseases, transient thyroiditis and other factors, the patient due to the decline in the body’s metabolic rate as well as the decline in sympathetic excitability, which may lead to amenorrhea, the phenomenon of the 50-year-old menstruation suddenly do not come. Women who are 50 years old and whose periods suddenly stop coming are advised to be admitted to the hospital for examination and to be treated accordingly after the cause has been identified.