1.The lesion of breast hyperplasia is confined to one quadrant of the unilateral breast, especially in the outer upper quadrant of the breast; the lump is large and hard in texture, and the effect of conservative treatment is not obvious. 2.Age > 35 years old, with a family history of maternal breast cancer, and nodular breast lumps that have not been significantly reduced by various treatments. 3.Existing hyperplastic breast lumps that increase rapidly within a short period of time. 4.In the process of observation and treatment of the original breast hyperplasia, the symptoms and signs have increased recently, and the results of mammography and other imaging examinations such as mammography and needle aspiration cytology examination have progressed compared with the previous examination, suggesting the possibility of malignant change. 5, post-menopausal older women with newly emerged “breast hyperplasia”, such as breast pain, glandular thickening, etc.. Patients with mastoproliferative disease should undergo excision or simple mastectomy for hyperplastic masses after needle aspiration cytology or biopsy to confirm that the epithelial cells of the breast are actively proliferating and even starting to have heterogeneous changes. If necessary, intraoperative frozen section pathological examination is performed.