Thin eyelid skin, loose subcutaneous tissue, and stimulation by various physical and chemical factors can easily cause eyelid edema. Waking up with swollen upper eyelids may be caused by non-disease factors such as poor rest or drinking too much water the night before, and after excluding such cases, it may be caused by pathological factors such as inflammatory reactions. I. Non-disease factors: If you did not rest well the night before or drank a lot of liquid before going to bed, it can lead to congestion and edema of the eye tissue and the above-mentioned situation, but it is usually not accompanied by other symptoms and can be relieved naturally after proper rest and other treatments, without leaving any adverse effects. In order to avoid such situations, it is recommended to pay attention to rest and avoid drinking large amounts of liquid before bedtime. Second, disease factors: 1, inflammatory reaction: such as wheals, usually caused by bacterial infection, at this time, the patient in addition to waking up swollen upper eyelids, but also accompanied by local redness, fever, pain and other performance. For such patients, anti-inflammatory treatment is usually required in a timely manner, and medications such as erythromycin eye ointment can be applied as prescribed by the doctor. In addition, if an allergic reaction occurs, the upper eyelid may be swollen and itchy upon waking up, possibly due to dust mite allergy. At this time, patients can follow medical advice to take loratadine tablets and other drugs for treatment, but also need to change the pillow towel, open the window ventilation, etc.; 2. Pathological edema: usually caused by cardiac insufficiency, renal insufficiency, etc., in which edema caused by cardiac insufficiency may be caused by insufficient cardiac output and blood stagnation, while edema caused by renal insufficiency may be a large amount of proteinuria caused by hypoproteinemia. When the plasma colloid osmotic pressure decreases, water can enter the tissue interstitial space, resulting in edema. Therefore, there are more causes of swollen upper eyelids upon waking up, and it is not easy to identify them on your own. People with these conditions should seek prompt medical attention and may need to be treated with diuretic drugs such as furosemide tablets as prescribed by the doctor.