After ruling out the corresponding drug contraindications, febuxostat can be used with diclofenac sodium. Diclofenac sodium is a kind of common non-steroidal anti-inflammatory drugs through the inhibition of cyclooxygenase to reduce the synthesis of prostaglandins to play the effect of antipyretic, analgesic effect, febuxostat is a kind of uric acid lowering drugs mainly used for long-term control of hyperuricemia in gout, febuxostat and diclofenac sodium has not been found to have drug interactions or contraindications for the time being, therefore, after excluding contraindications to the use of two drugs can be used in conjunction with the drug. Allergic to febuxostat and patients being treated with azathioprine and mercaptopurine should not be treated with febuxostat. Diclofenac sodium treatment is prohibited in patients with severe heart failure, hepatic failure, renal failure and other contraindications to the use of diclofenac sodium. Febuxostat and diclofenac sodium should be used under the guidance of a physician, and it is recommended that patients go to the rheumatology and immunology departments of regular hospitals and other related departments for detailed consultation.