First of all, let’s clarify the concept that there are many factors affecting infertility, and advanced age is only one of them. The causes of infertility can be broadly divided into female and male causes. Male causes include sperm dysfunction, abnormal sperm transport, endocrine and systemic diseases, and idiopathic infertility. Female causes include: 1. ovulation disorders 2. endometriosis 3. pelvic adhesions 4. tubal obstruction 5. hyperprolactinemia 6. unexplained infertility Generally speaking, female fertility starts to decline gradually around the age of 30, and the rate of fertility decline becomes faster with age. The impact of ageing on female fertility is multifaceted and the most affected is the ovarian reserve capacity (number and quality of eggs). Each woman has a fixed number of eggs from birth, and the number and quality of eggs diminish with age, a process that occurs irreversibly. At the same time, the probability of the occurrence of chromosomal abnormalities in the eggs is elevated. In addition, factors affecting female infertility such as fluid in the fallopian tubes, pelvic inflammatory disease, and smooth muscle tumors also increase in likelihood of occurrence. Therefore, if the female partner is older than 35 years old, we recommend that the couple see a medical professional for an evaluation of factors related to infertility as soon as possible after six months of unprotected intercourse. However, for women younger than 35 years old, the evaluation of infertility-related factors can be done after one year of unprotected intercourse. Therefore, for women with advanced infertility, we recommend that you visit a specialized fertility center as soon as possible to determine the cause of infertility, and then choose a plan that is appropriate for you based on the results of ancillary tests such as age, ovarian reserve function, duration of infertility, fallopian tubes, and the condition of the male partner.