How long does it take to wake up from a hepatic coma varies according to each person’s condition. With active treatment, people usually wake up in 3 to 4 days. Depending on the degree of hepatic coma, appropriate medications can be given. Arginine and Mentholatum can be used to lower blood ammonia and Mannitol can be used for dehydration under the supervision of a doctor. Lactulose or enemas can also be used to improve the intestinal environment and reduce the absorption of toxins from the intestines, which can help to wake up from a hepatic coma. If medication is given and the results are not satisfactory and the patient with hepatic coma does not wake up, liver transplantation or artificial liver treatment can be chosen according to the patient’s own condition. Family members of patients with hepatic coma should keep the environment clean, keep the patient’s respiratory tract open, ensure the supply of oxygen, and do a good job of oral and eye care.