Sleepless nights in cirrhotic patients may be associated with emotional stress, anxiety and depression, being in the prodromal stage of hepatic encephalopathy, and abdominal pain. Patients may be overly worried about the disease, resulting in emotional stress and an inability to sleep normally, which requires personalized emotional counseling from a professional to guide the patient to relax his or her emotions. Cirrhosis can also be combined with anxiety and depression and other mental illnesses, resulting in the patient’s loss of confidence in the hope of life and the cure of the disease, which may also be manifested in sleepless nights, and at this time, antidepressant and anti-anxiety treatment should be carried out under the guidance of specialized physicians. When the condition of cirrhosis progresses to the prodromal stage of hepatic encephalopathy, the patients will have hyperactive mental symptoms, at this time, there may be symptoms such as euphoria, anxiety, sleep inversion and so on. A large amount of ascites is often formed in the decompensated stage of cirrhosis, resulting in obvious abdominal distension and pain, which affects the patient’s sleep quality and even prevents him/her from sleeping. If patients with cirrhosis experience sleeplessness all night, they should seek medical treatment in time and under the guidance of doctors.