Knee closure mostly refers to medicated closure treatment of the knee joint. Pain recurrence after one week of treatment may be due to a more severe knee injury and less effective closure treatment. The treatments that can be taken include general treatment, medication and surgery. 1. General treatment: If you do not have a good rest after drug closure treatment, premature weight-bearing exercise may affect the therapeutic effect. You can rest properly and reduce the weight-bearing exercise of the lower limbs. 2. Medication: Oral non-steroidal anti-inflammatory drugs, such as diclofenac sodium extended-release tablets to reduce inflammation and pain, can also be combined with acupuncture, massage and other treatment modalities. 3. If the conservative treatment is not effective and the knee pain causes difficulty in walking, which seriously affects your life, you can consider surgical treatment, such as knee arthroplasty. If the pain recurs after one week of medication closure of the knee joint, it is recommended to consult a doctor in time and follow the doctor’s instructions.