Whether taking amoxicillin and acyclovir topical application for epididymal hardness is useful needs to be judged according to the etiology of epididymal hardness and so on. Generally speaking, most epididymal hardness is mainly caused by inflammatory stimulation, such as common chronic epididymitis, mainly caused by bacterial, viral and other pathogenic microorganisms infection. So for bacterial infection caused by epididymal hardness, can be anti-inflammatory and treatment through antibiotic drugs, this time to take amoxicillin can play a role in anti-inflammatory, reduce swelling. Amoxicillin belongs to the β-lactam antibiotics, penicillin drugs, can play an anti-inflammatory role, but some patients taking drugs, easy to nausea, vomiting, diarrhea, rash, anemia and other adverse reactions; and for penicillin allergy and penicillin skin test positive patients prohibited the use of the drug, so as not to cause allergies. Acyclovir belongs to the antiviral drugs, if it is because of herpes simplex infection caused by epididymal hardness, can be applied externally or oral acyclovir, can play a certain antiviral effect, so as to play a certain therapeutic effect. However, some patients are prone to pain, burning, tingling, redness and other adverse reactions during the use of the drug, which should be taken seriously; in addition, pregnant women, lactating women, children and allergy patients should be cautious about using it. The use of specific drugs, need to be under the guidance of a professional doctor, follow the doctor’s instructions to take.