There is fire in the large intestine is also known as the large intestine heat knot evidence, its symptoms include abdominal fullness, distension and pain, refusing to press, dry stools, or heat knot flow, hot flashes (a burst of fever) and so on. The large intestine heat knot evidence belongs to the name of Chinese medicine, refers to the evil heat injury, dry solid knot, so that the large intestine conduction failure, viscera gas can not pass the evidence. Clinical manifestations are abdominal fullness, distension, pain and refusal to press, dry stools, or heat knot flow, hot flashes, red face, thirst, short and red urine (urine is small in volume and dark yellow in color), yellow and dry tongue, or burnt black and prickly, with a solid or strong pulse. Heat knot evidence in the large intestine is commonly found in constipation, abdominal pain, typhoid fever (diseases in which fever is caused by feeling cold) yangming disease, and wen disease. In western medicine, this syndrome can be seen in the course of acute abdomen caused by various reasons, habitual constipation, and exogenous high fever and emergency. This syndrome can generally be treated with Liang Diaphragm San, Da Chai Hu Tang, Da Cheng Qi Tang and other drugs under the guidance of a physician. It is forbidden for those who are allergic to the above drugs. If the above symptoms occur, it is recommended to consult a hospital and standardize the treatment under the guidance of a physician, do not use medication without authorization to avoid causing adverse reactions.