Swelling of the face may be related to hypoproteinemia, cardiac failure, nephrotic syndrome, as well as drugs, allergies and other factors. 1. Hypoproteinemia: it means that the total serum protein is less than 60g/L or the albumin is less than 35g/L, and the causes of its development mainly include severe anemia, infection, kidney disease, tumor and other factors. 2. Cardiac failure: when cardiac failure occurs, the anterior and posterior loads of the heart will increase, which will lead to the obstruction of blood reflux, thus causing water and sodium retention, mainly manifested as edema. 3. Nephrotic syndrome: this is a serious threat to human health, mainly related to glomerular function abnormalities caused by a variety of factors, the examination will show a high degree of edema, hyperlipidemia, hyperproteinuria and hypoproteinemia and so on. 4. Influence of drug factors: some drugs can produce some side effects when taken in large doses for a long time, such as methylprednisolone tablets, prednisolone tablets and other glucocorticosteroid drugs, which can cause facial edema. Allergy can also cause facial edema, the specific circumstances need to ask the doctor to interview, and combined with other clinical manifestations and laboratory results for analysis.