Tacrolimus ointment can be used to treat white spots, but it should be administered under medical supervision after the cause of the white spots has been clarified. Leukoplakia is a collective term for diseases that mainly manifest themselves as white patches on the skin, such as vitiligo and pityriasis alba. Usually, tacrolimus ointment can treat white spots caused by vitiligo and pityriasis alba, which has the effect of immunosuppression and inhibition of T-lymphocyte activation, and is effective for white spots. Tacrolimus Ointment is commonly used in the treatment of non-immuno-compromised patients with moderate to severe atopic dermatitis who are unfit for conventional therapies due to potential dangers, who do not respond well to conventional therapies, and who are unable to tolerate conventional therapies, and it can be used for short-term or intermittent long-term treatment. Adverse reactions such as visual abnormalities, anemia, and anorexia may occur with use in some populations. Tacrolimus Ointment is contraindicated in individuals who are allergic to its ingredients. For people who need to use tacrolimus ointment topically to treat white spots, it is recommended to go to a regular hospital to consult a doctor and use the medication under the doctor’s guidance, avoiding unauthorized use of medication.