Azelaic acid can generally treat melasma and can be effective. However, the treatment of melasma firstly needs to do a good job of daily sun protection, and secondly, it can also be improved with physical therapy. Melasma is a kind of common skin pigmentation spot on the face. The cause of melasma is still unclear, and it may be caused by factors such as genetic susceptibility, sun exposure, and changes in sex hormone levels. Azelaic acid can often be used to treat melasma and can act as an adjunctive treatment to help reduce hyperpigmentation. However, the primary basis of treatment for melasma is sun protection, including the wearing of umbrellas and sun hats. In addition, patients can be treated with physical therapy, such as laser treatment. Laser treatment can penetrate into the deep layers of the skin, decompose the pigment inside the deep layers of the skin and excrete it out of the body with metabolism, so as to achieve the effect of lightening and removing the pigment. The purpose of chloasma treatment is to make the color spots become lighter, return to normal or decrease in area and fade away. Patients should firstly avoid triggering factors, especially sun protection, and reasonably use topical drugs on the basis of sun protection. Patients need to use medication under the guidance of doctors and should not use medication without authorization, and should cooperate with doctors for standardized treatment.