The quadruple therapy for gastritis is mainly for patients with positive H. pylori. The medication of quadruple therapy is based on antibacterial drugs, drugs to protect the gastric mucosa, and drugs to inhibit gastric acid mainly proton pump inhibitors. Commonly used antibacterial drugs include amoxicillin capsules, tinidazole tablets, clarithromycin capsules, proton pump inhibitor drugs commonly used are omeprazole capsules, lansoprazole dispersible tablets, rabeprazole sodium enteric capsules, and drugs to protect the gastric mucosa include thioglycollate aluminum tablets and bismuth pectin. In the clinical treatment with the role of spleen nourishing stomach of proprietary Chinese medicine, commonly used are gastroenterology dispersible tablets, lactobacillus tablets, after taking better results, gastritis quadruple medication must be standardized, continuous treatment effect is obvious.