Sore throat, common in acute pharyngitis, acute laryngitis, laryngeal cancer, reflux pharyngitis and other diseases, need to identify the cause, for specific diseases for treatment, there is no “sore throat” for the most useful drugs. 1. Acute pharyngitis: patients can use antibiotics under the guidance of a doctor to control the infection, commonly used drugs are penicillin, cefaclor and so on. 2. Acute laryngitis: glucocorticoids can be used to quickly reduce mucosal edema, inhibit the release of inflammatory mediators, common drugs are dexamethasone, prednisone. Use penicillin, acyclovir and other drugs to treat the cause. 3. Laryngeal cancer: cisplatin, carboplatin, paclitaxel and other chemical drugs can be used to kill cancer cells. Cetuximab and other drugs can also be used to stop tumor angiogenesis. 4. Reflux pharyngitis: it can be treated with proton pump inhibitors (omeprazole), histamine H2 receptor antagonists (famotidine), and prokinetic drugs (domperidone). There are many causes of sore throat, it is recommended to actively go to the hospital for a clear diagnosis and standardized medication and treatment.