Urine can not come out, consider mostly due to urethral stones, prostate hyperplasia, urinary tract infections and other effects caused. 1. Urethral calculi: are due to a variety of factors, such as gender, dietary factors, genetic factors, environmental factors and other factors lead to the stone embedded in the urethra, it will be manifested in urinary difficulties, urinary dribbling, or urinary pain, urinary incontinence and so on. 2. Prostatic hyperplasia: the cause of the complexity of the etiology, mostly related to sex hormones and their receptors, inflammation, growth factors neurotransmitters, etc., will be manifested as increased urination at night, dysuria, painful urination, urinary urgency, urinary dribbling, and so on. 3. Urinary tract infection: mostly due to pathogenic microorganisms caused by urinary tract infectious diseases, mainly manifested as urinary frequency, urinary urgency or urinary difficulty, pubic discomfort, urethral burning sensation. Difficulty in urination may also be caused by other factors, it is recommended that patients go to the regular hospital in a timely manner to seek treatment, and strive for early recovery.