Although stomach and esophagus are connected together and closely related, clinically they actually belong to two different tissues, and the difference is in the following aspects: 1. site of incidence, esophageal cancer develops in esophagus, while gastric cancer is mostly seen in gastric lesions; 2. histology, the surface of esophagus is mostly compound squamous epithelium, while the surface of stomach is mucosal epithelium; 3. clinical manifestations, clinical manifestations of gastric cancer include abdominal distension and pain, anemia, nausea, etc., while esophageal cancer is commonly known as Esophageal cancer is commonly known as esophageal cancer, and the typical clinical manifestation is progressive dysphagia; 4.Treatment, both esophageal cancer and gastric cancer can be removed surgically. However, esophageal cancer is very sensitive to radiotherapy, so radiotherapy for esophageal cancer is very effective. While most of gastric cancer is adenocarcinoma, which has some sensitivity to chemotherapy.