Glycated antigen 125 high after lung adenocarcinoma surgery may be recurrence or metastasis of lung adenocarcinoma, or poor treatment effect, or gynecological diseases or gynecological and digestive malignant tumors, etc., which should be further examined to confirm the diagnosis. Glycated antigen 125, abbreviated as CA125, is commonly used in early screening of gynecological malignant tumors such as ovarian cancer and digestive malignant tumors such as gastric cancer, in addition, benign diseases such as pelvic inflammatory disease and uterine fibroids may also cause elevation of CA125. Therefore, CA125 is only used as an auxiliary screening tool, and further relevant examinations are needed to clarify the diagnosis. If lung adenocarcinoma recurs or metastasizes, or if the treatment effect is not good, resulting in an increase in the number of cancer cells in the body, CA125 may also be elevated. If patients have high CA125 after lung adenocarcinoma surgery, it is recommended to consult a doctor in time and adopt corresponding treatment plan under the guidance of the doctor.