Oral capecitabine alone may be beneficial to patients, and the specific efficacy is related to the pathological type and stage of patients as well as their general physical condition. Capecitabine is a more effective chemotherapeutic drug for the treatment of intestinal cancer, and it is commonly used as adjuvant chemotherapy after resection of colon cancer, which is effective to a certain extent, but not all patients are able to achieve better therapeutic effects, and most of them are still recommended to have combined chemotherapy, such as combining with oxaliplatin, and so on. Patients with advanced stage or unable to tolerate high-dose chemotherapy can also take a small amount of oral capecitabine to improve the quality of life of patients. Therefore, whether colon cancer can benefit from oral capecitabine alone needs to be evaluated according to the patient’s specific situation.