Benidipine and amlodipine are both calcium channel blockers, the composition of the two are different, the patient’s sensitivity and response to the drug are also different, the therapeutic effect is also different, there is no so-called “which one is better”, the patient should follow the doctor’s instructions to use the drug. Benidipine and amlodipine are both used in the treatment of essential hypertension and angina pectoris. Benidipine is a dihydropyridine calcium antagonist, the main ingredient is benidipine hydrochloride. The main components of amlodipine are maleic acid, mentholatum, amlodipine, etc. Its anti-hypertensive mechanism of action is direct relaxation of vascular smooth muscle. Compared with the two drugs, Benidipine is faster absorbed orally, has a long-lasting antihypertensive effect, and does not produce drug resistance when administered for a long period of time. Some patients using Benidipine may have serious adverse reactions such as liver function impairment, jaundice, and sometimes lower blood pressure, palpitations, edema, constipation, etc. Once abnormalities occur, the drug should be stopped immediately and treated accordingly by a doctor. Amlodipine, on the other hand, is better tolerated and has relatively mild adverse effects, commonly including fatigue, flushing, dizziness, abdominal pain, etc. Less common side effects include dry mouth, weakness, and abnormal sensation. Benidipine and amlodipine are both prescription drugs, it is recommended that patients with hypertension should consult a doctor in a timely manner, and the doctor should select appropriate and effective drugs for treatment according to the specific condition, individual constitution, etc. Patients should not use the drugs on their own, so as to avoid the treatment being ineffective or delaying the condition.