Whether advanced lung cancer can still be treated with chemotherapy at old age depends on the patient’s own condition and the effect of disease control. Treatment of advanced lung cancer is mainly based on chemotherapy, targeted therapy, immunotherapy and other non-surgical treatments. Chemotherapy, as an important part of advanced lung cancer treatment, requires scientific and accurate evaluation of the comprehensive status of the body for elderly patients. If the patient’s physical status and the functions of organs are good, standard chemotherapy program can be given; if the physical status is a little bit poorer, chemotherapy should start from a low dose, or adopt the program of splitting the dose and prolonging the cycle. However, if one’s state is relatively poor and insensitive to chemotherapy, the effect of treatment is relatively poor and the cancer cells are not controlled; and the adverse reactions after treatment are relatively strong, such as nausea, vomiting, obvious bone marrow suppression, etc., chemotherapy can be exempted, and other treatments can be used to control the cancer cells, such as targeted therapy and immunotherapy. To sum up, the treatment of older lung cancer patients needs to be considered by combining many factors, and it is recommended that patients should go to regular hospitals for consultation and choose appropriate treatment plans under the guidance of doctors.