If you’re looking for an acute purulent urethritis, you need to take oral medication according to the type of bacteria that are infecting you. First, acute purulent urethritis is commonly caused by E. coli, Staphylococcus aureus and other infections, so you need to take genital pus for bacterial culture examination and select sensitive antibiotics according to the culture results. Cefixime capsules can be used twice a day for one week orally. If there are symptoms such as frequent urination, urgent urination, painful urination or fever, intravenous antibiotics are recommended. Generally, cefuroxime can be chosen as intravenous injection of 1.5 grams twice daily for one week. Secondly, gonorrhea, that is, gonococcal infection, at this time, it is necessary to retain pus for gonococcal smear or culture examination. If gonorrhea is diagnosed, it is recommended to use ceftriaxone sodium 1 gram twice daily by intravenous infusion for 7-10 days. Third, non-gonococcal urethritis, need to take pus for culture, if the culture suggests mycoplasma, chlamydia infection, it is recommended to use azithromycin oral or intravenous infusion treatment. If there is a combination of urinary frequency, urinary urgency, painful urination with fever symptoms, then direct infusion treatment is used. Generally, azithromycin 0.5 g can be chosen as an IV once daily for 7-10 days.