There are many reasons for pain in the middle of the chest during inhalation, such as lung disease, pleurisy, intercostal neuralgia, and so on. 1. Lung diseases: Pneumonia, tuberculosis, lung tumors, etc. can cause pain in the middle of the chest when inhaling, accompanied by coughing and coughing. 2. Pleurisy: Pleurisy can also cause pain in the middle of the chest when inhaling, especially when the chest expands during inhalation, so there will be pain. 3. Intercostal neuralgia: Intercostal neuralgia can also cause pain in the middle of the chest during inhalation, especially when inhaling, the ribs will be involuntarily upward, which will lead to pain in the middle of the chest. There are many reasons for pain in the middle of the chest during inhalation, so it is recommended to go to the hospital in time to improve the examination and take standardized treatment according to the doctor’s instructions, and not to ignore the symptoms and take them lightly.