There is no such thing as what medicine is the most effective for removing chloasma, you should choose the suitable medicine according to the individual difference and combine with your own situation. It is suggested that you can take vitamin C, vitamin E, tranexamic acid, glutathione and other medicines orally. 1. Vitamin C and Vitamin E: Vitamin C and Vitamin E can play a role in inhibiting melanin synthesis and have a strong anti-lipid peroxidation effect, and can be taken orally or injected intravenously. 2. Tranexamic acid: It has certain effect on removing melasma, but there are some side effects after using it, such as gastrointestinal reaction, menstrual bleeding, it is suggested to follow the doctor’s instruction to use the medicine scientifically, and it is forbidden to use it for the patients who suffer from thrombosis, angina and stroke. 3. Glutathione: Glutathione is usually used in combination with vitamin C, which can play the role of melasma, and can be used orally or intravenously. To get rid of melasma, it is recommended to combine with the condition of individual pigmentation, go to regular hospitals to do relevant examination, and choose appropriate treatment according to the situation.