Inevitably, accidents happen in daily life, and the skull may be damaged by external force majeure, and cranial defect is a relatively common disorder in neurosurgery. For example, traffic accidents, production safety accidents, falling objects, fights, cranial surgeries, etc. may damage the skull and eventually cause skull defects. This requires timely cranial repair surgery, but some patients may still have a fluke mentality. If a skull defect occurs and the diameter of the defect is more than 3CM, skull repair is recommended. If skull repair surgery is not performed in time, one of them will have a great impact on the aesthetic appearance, and the lack of part of the skull will cause drastic changes in the intracranial environment, unstable intracranial pressure, the cerebrospinal fluid circulation and cerebral blood circulation may be affected, and the neurological function of the skull may be impaired, resulting in a series of skull defect syndrome, which will affect the physical and mental health of the whole person. Another important point is safety, if not repaired in time, if the head is re-injured, it may directly harm the brain tissue, and in serious cases, it may even directly endanger the life, which is very dangerous. Therefore, it is very necessary to have skull repair surgery in time. The repair material is very important for skull repair surgery, and the technique is also very important. Currently, our team performs PEEK cranioplasty with good clinical results. We suggest patients with skull defects to go to the hospital early to choose the right material to repair their skull and regain their health as soon as possible.