Mannitol and glycerol fructose are the most common dehydration drugs, most commonly used in cerebral hemorrhage, cerebral edema, can be used separately or in combination, the main differences between the two are as follows: 1, duration of action: mannitol has a faster onset of action, but a shorter duration of action, glycerol fructose has a relatively mild effect, but a longer duration of action; 2, whether diuretic: glycerol fructose does not have a diuretic effect, while mannitol can achieve The effect of diuretic. Therefore, the dehydration effect of mannitol is relatively stronger than glycerol fructose, and the diuretic effect is also stronger than glycerol fructose; 3, the effect on blood sugar: glycerol fructose contains fructose, which is more likely to raise blood sugar in diabetic patients, but mannitol does not have as high requirements for diabetic patients, and has less effect on blood sugar; 4, the requirements of kidney function: mannitol has higher requirements for kidney function, and generally patients with severe renal insufficiency and anuria cannot use mannitol. Mannitol cannot be used in patients with severe renal insufficiency and anuria. Mannitol has the effect of dehydration and diuresis, and when used by patients with renal insufficiency, it cannot be dehydrated, and the water gathered in the kidneys is toxic instead. Because glycerol fructose has a milder effect, the requirements for kidney function are not as strict as those for mannitol.