Prolonged gurgling with diarrhea indicates that the bowel sounds are hyperactive and gastrointestinal peristalsis is accelerated, which may be caused by infections, dietary abnormalities or irritable bowel syndrome, etc. Patients can take dietary adjustments, medication and other methods to control the cause of the disease. 1. Infection: long-term stomach grumbling with diarrhea may be caused by bacterial infection, patients can take levofloxacin, norfloxacin and other antibiotic drugs. 2. Dietary abnormalities: Eating cold and spicy food can easily cause irritation to the stomach and intestines, causing the above symptoms. Patients should pay attention to strict diet control and eat light and nutritious food. 3. Irritable bowel syndrome: due to the increase in intestinal dynamics, it will trigger the intestinal smooth muscle contraction sensitivity, intestinal peristalsis hyperactivity, feces rapid passage through the intestinal tract, it will cause intestinal tinnitus. 4. Inflammatory bowel disease: in the acute stage, there may be diarrhea, abdominal pain, fever, intestinal tinnitus and other manifestations, you can use Liuzosulfapyridine to control inflammatory bowel disease in the mild to moderate active stage, but also can be used to prednisone and other glucocorticosteroid therapy; accompanied by perforation, hemorrhage and other cases need to consider surgical treatment. Long-term stomach grumbling with diarrhea may also be caused by other reasons, it is recommended that the patient should go to the hospital in time to receive treatment, and should also pay attention to follow the doctor’s instructions during the use of medication.