Swelling and pain in the thumb of the foot can be caused by gout. In the acute stage, oral non-steroidal anti-inflammatory drugs, diclofenac or celecoxib can be applied, and local saline wet compresses can also be applied to alleviate the patient’s discomfort. In addition, there are patients with arteriosclerosis of the lower extremities, which may also manifest as localized pain due to insufficient blood supply. If there is a soft tissue infection, there is also significant swelling, and oral medication to improve microcirculation and vasodilatation should be taken, commonly known as beraprost sodium tablets. Some patients with localized or distal soft tissue infection of the limb secondary to diabetes may also have significant fever. Oral anti-infective medications should be administered, broad-spectrum penicillin V potassium tablets should be applied, and surgery for incision and drainage should be an option if necessary.