Angioneurotic edema is most often considered when waking up with a swollen mouth. This disease is mostly related to allergies, which may be caused by exposure to allergic foods and medications. It is likely to occur in areas with loose skin tissue, such as eyelids and mucous membranes of the mouth and lips, and in severe cases, it can lead to laryngeal edema with respiratory distress. It may appear as a shiny, ill-defined swelling on the skin surface, accompanied by pain and discomfort. It is possible to take oral anti-allergy drugs such as levocetirizine hydrochloride tablets and loratadine tablets for desensitization, which will not leave traces after treatment.