The clinical manifestations of Crohn’s disease mainly include gastrointestinal symptoms, such as abdominal pain and diarrhea; as well as systemic symptoms, such as fatigue and weight loss; and there may even be extra-intestinal manifestations, such as bone disease and skin manifestations. It is recommended to consult a specialist. 1. Gastrointestinal symptoms: mainly pain in the right lower abdomen, and in severe cases, intestinal obstruction or intestinal perforation, such as sudden severe abdominal pain or paroxysmal aggravating abdominal pain with abdominal distension, nausea and vomiting, etc. If it involves the perianal area, it can be accompanied by pain and pus secretion at the anus. 2. Systemic symptoms: in severe cases, malaise, fever, malnutrition, emaciation and so on. 3. Extra-intestinal manifestations: often related to autoimmunity, it can cause bone disease, such as arthritis, sacroiliac arthritis, etc., skin manifestations such as erythema nodosum, eye damage, such as conjunctivitis, etc., and also renal stones, primary sclerosing cholangitis, thrombophlebitis, oral ulcers, asthma and so on. Those who suspect Crohn’s disease need to consult a doctor in time to avoid delay.