Chromosome 47,XXY is Klinefelter syndrome, a common disorder of sex chromosome abnormality, which is caused by the non-separation of homologous chromosomes or sister chromatids of the X chromosome during meiosis during the formation of biparental embryos, resulting in some of them having an extra X chromosome, which combines with normal gametes to form a 47,XXY syncytium. Crohn’s syndrome is also the most common cause of male hypogonadism, with typical clinical manifestations of tall stature, hypogonadism, infertility, and gynecomastia. Parental exposure to environmental pollutants, drugs, radiation, hot environments, and advanced age may predispose to this condition.