If the heart does not feel well after staying up late, usually because of sympathetic overexcitation, resulting in imbalance of neurohumoral and endocrine system, then the patient will have symptoms of precordial discomfort, at this time should immediately stop staying up late, and choose bed rest as the main, the patient in bed rest can be appropriate sublingual quick-acting heart pills or nitroglycerin, observe whether the precordial pain and other symptoms have been alleviated. In addition, the patient should be given oxygen therapy, continuous low-flow oxygen, if possible, should try to improve myocardial enzymology and eighteen-lead ECG examination, and can take anti-platelet aggregation drugs, such as aspirin, clopidogrel and other drugs, and in severe cases can also take nitrate drugs.