Earth kinase is an enzyme complex with fibrinolytic effect, which can reduce fibrinogen content, shorten the time of euglobulin lysis, enhance the activity of tissue-type fibrinogen activator, and reduce the activity of fibrinogen activator inhibitor; it can also reduce the whole blood viscosity as well as plasma viscosity. The common dosage forms of earth kinase are enteric capsules, enteric-coated tablets, etc. It is clinically used for the treatment of ischemic cerebrovascular disease with increased fibrinogen and platelet aggregation rate. Adverse effects of earthworm kinase include headache, dizziness, rash, skin itching, elevated eosinophils, nausea, vomiting, stomach upset, increased frequency of loose stools, constipation and other symptoms. The use of drugs need to pay attention to: to earth kinase allergy is prohibited, acute bleeding patients should not be used, bleeding tendency of patients should be used with caution, pregnant women and lactating women should be cautious, the safety and efficacy of the use of drugs in pediatric patients is not clear. If you need to use earthworm kinase, it is recommended to consult a professional doctor, follow the doctor’s instructions for standardized treatment, not blindly use the drug on their own.