Anterior mediastinal nodule of 1.6 cm is found, which may be benign tumor, malignant tumor and metastatic tumor, and the specific treatment plan includes regular review, surgical resection and radiotherapy. 1. Benign tumors: mainly include lipoma, which itself does not cause clinical symptoms and can be reviewed regularly without too much intervention; thymoma causes myasthenia gravis and mature teratoma occupies the position, which needs to be treated by surgical resection. 2. Malignant tumors: the most common one is invasive thymoma, which should be radically resected through surgery as early as possible after the discovery of the corresponding lesions, and some of them need to be assisted with radiotherapy; there are also immature teratomas, which may also need radiotherapy after surgery. 3. Metastatic tumor: primary tumors in other parts of the body may metastasize to the anterior mediastinum and cause corresponding changes, and most of them need to be controlled by radiotherapy, which is usually chosen as extracorporeal radiotherapy; commonly used chemotherapeutic drugs include cisplatin and paclitaxel. If a 1.6 cm anterior mediastinal nodule is found, causing obvious chest pain or increasing in size during review, it is necessary to be admitted to the hospital in time for examination, and standardized treatment should be carried out under the guidance of the clinician after diagnosis of the disease, so as to avoid delay of the disease.