Patients who suddenly experience a distinct itching sensation on their face and feel rougher to the touch should consider the occurrence of skin allergies in this case. The reason why the face may feel rougher to the touch is that small bumps actually appear on the face. Patients can first take oral antihistamines for treatment, like loratadine, cetirizine, paracetamol, ibastine tablets, and fexofenadine, usually one of them can be taken orally. Patients who have the conditions can also apply glyburide lotion for application, can also effectively relieve the local obvious itchy feeling, patients who have mask paper at home, can also apply saline to soak it and then wet compress to the face, or can also apply gauze application saline wet after wet compress solution, can also play a calming and soothing role. If the patient is not effective in applying oral medications and topical medications, it is best to go to the hospital to apply glucocorticoids and calcium gluconate intravenously.