Thalassemia is characterized by severe, intermediate and mild forms. Patients with severe form can present with anemia, progressive worsening of hepatosplenomegaly, jaundice, and dysplasia from the first few days of life. Special manifestations include a large head, widened eye spacing, saddle nose, prominent forehead, prominent cheeks, and typically a gluteal head with fractured long bones. Skeletal changes are caused by hyperhematopoiesis of the bone marrow, widening of the bone marrow cavity, and thinning of the cortex. In a few patients, thoracic masses occur between the ribs and spine. Gallstone disease and lower extremity ulcers may also be seen. The intermediate type may have mild to moderate anemia, and most patients with anemia survive into adulthood. Patients with the mild type have mild or no symptoms of anemia and are usually found during family history investigations. Therefore, pregnant women with thalassemia, usually those with the mild or intermediate type, should have symptoms that are a little more pronounced than the symptoms of the disease in the norm. Usually, there may be symptoms of anemia such as weakness, dizziness and pallor, which can affect the health of the fetus and may lead to severe anemia, and some fetuses may not even develop normally. Therefore, it is recommended to go to the hospital for a series of tests such as appropriate routine blood tests, hemoglobin tests and genetic analysis of thalassemia.