After small incision cardiac surgery such as right axillary incision, small incision in the middle and lower sternum and thoracoscopy-assisted surgery, the Department of Cardiac Surgery of the First Hospital of Guangzhou Medical University has been the first to open minimally invasive atrial septal defect blocking, ventricular septal defect blocking, arterial catheter blocking and pulmonary valve balloon dilation in Guangdong Province since July 2013. At present, we have successfully completed more than 800 cases, which are at the advanced level in China. The technology is mature and stable, the incision is small, only 1-2cm, avoiding the traumatic median sternotomy and lateral thoracotomy, no extracorporeal circulation and cardiac arrest, blood transfusion, rapid resuscitation in the operating room, most of them do not require indwelling drains, fast recovery, you can get out of bed on the first day after surgery, and you can be discharged in about 3 days. The surgical scars are small and hidden, not easily detectable, and avoid the long-term psychological trauma caused by traditional surgical scars. Director Shaobo Xie perfectly combines interventional occlusion and surgery, and pioneered transjugular septal defect occlusion, which requires only one 2mm incision and smaller scars, and has achieved good results. Ventricular septal defect closure: Simple ventricular septal defect accounts for more than 50% of congenital heart surgery in our cardiac surgery department, of which 70% are performed by minimally invasive closure surgery with 90% success rate. Under the leadership of Director Shaobo Xie, the cardiac surgery team uses individualized incisions according to the size of the defect, distance from the aortic valve, location, shunt direction, and combined malformations of the patient’s ventricular septal defect. Among them, more than 100 cases of inferior stem type and intracrural type defects have been successfully sealed through small left parasternal incisions, avoiding the disadvantages of minimally invasive incisions in the lower sternum, with smaller and more beautiful incisions, and greatly shortening the operation time. In addition, the Department of Cardiac Surgery has carried out small incisional closure via the right parasternal sternum for some perimembranous defects with good results. Arterial catheter occlusion: Traditionally, left posterior lateral incision and axillary incision are used, which are long and traumatic; however, the minimally invasive arterial catheter occlusion carried out in our cardiac surgery department only requires a small incision of 1.5-2.5 cm, which is less traumatic and has a fast recovery rate, and more than 50 cases have been completed so far with a success rate of 100%.