For thylakoid proliferative glomerulonephritis, the common treatment is immunosuppressive drug therapy, including prednisone, cyclophosphamide and so on. According to the different conditions of patients, the most appropriate and effective treatment is chosen. Immunosuppressive drug therapy is preferred to glucocorticoids, which inhibit the secretion of aldosterone and antidiuretic hormone by suppressing the immune-inflammatory response, thus affecting the glomerular basement membrane to exert the therapeutic effect of diuresis and elimination of urinary protein, and the commonly used medicines are prednisone, methylprednisolone and so on. For patients with hormone resistance or dependence, synergistic cytotoxic drug therapy is available. Common cytotoxic drugs such as cyclophosphamide are hydroxylated by hepatocyte microsomes in vivo, and the metabolites have a strong immunosuppressive effect. Nitrogen mustard phenylbutyrate also belongs to the cytotoxic drugs, but due to its own toxic side effects, it has been less used. All of the above medications should be used under the guidance of a physician, avoiding self-medication. If the patient suffers from proliferative glomerulonephritis, it is recommended to go to the regular hospital in time, under the guidance of the doctor to standardize the treatment.