Long-term use of Tibolone may cause weight gain. Tibolone Tablet is an exogenous estrogen replacement drug, which is mainly used for the treatment of menopausal syndromes such as sweating and hot flashes (bursts of heat) caused by natural menopause and surgical menopause. Patients may experience adverse effects such as vaginal bleeding, weight gain, dizziness, changes in liver function markers, and weight gain while taking the medication, so long-term use of Tibolone may cause patients to gain weight. Patients should use Tibolone drug under the guidance of a doctor, not blindly use the drug on their own to avoid adverse consequences, and it should also be noted that patients with severe liver disease and allergy to Tibolone ingredients are prohibited from using the drug. Before and during the use of the drug patients need to carry out regular checks to detect the thickness of the endometrium, if more than 5 millimeters or abnormal bleeding, it is recommended to consult a doctor for diagnosis in a timely manner.