The reference value of normal retinol binding protein in serum is (47.2±9.6) mg/L and in urine is (0.12±0.07) mg/L. The presence of low retinol binding protein is mainly associated with liver pathologies such as cirrhosis, obstructive jaundice, and impaired liver function. Retinol binding protein is a plasma binding protein that specifically binds retinol (vitamin A) and maintains the metabolism of retinol. Since retinol-binding protein is mainly synthesized by the liver, if a patient develops liver-related diseases, the liver is damaged and the liver’s protein synthesis function is subsequently reduced. In addition, vitamin A deficiency in the body can cause low retinol binding protein, mainly related to trauma, infection, malnutrition, hypoproteinemia, hyperthyroidism, etc., excessive consumption of body energy. Therefore, Retinol Binding Protein is an important indicator for detecting early liver and kidney diseases. If a patient has a low Retinol Binding Protein during physical examination, it is recommended that other related tests be performed under the guidance of a doctor to clarify the diagnosis and take targeted treatment. In daily life, attention should be paid to maintaining good living habits, quitting smoking and drinking, and avoiding fried and stimulating diets, such as hot pot and fried skewers. Avoid overexertion, proper activity and exercise, avoid excessive obesity, etc.