Total bile acids are also one of the liver function tests. Elevated total bile acid with normal liver function may be caused by normal physiological phenomenon, liver disease, gallbladder disease and other reasons. 1. Normal physiological phenomenon: total bile acid is the metabolite of cholesterol, which can reflect the metabolic function of the liver and the excretion function of the gallbladder. When taking too much animal offal, egg yolk and other foods with high cholesterol content, total bile acid may be elevated and other items of liver function are normal, and the total bile acid can be reduced to normal range after removing the triggers. 2. Liver disease: acute hepatitis, chronic hepatitis, cirrhosis and other liver diseases in the compensatory period, there may be liver parenchymal injury but total bile acid elevation of liver function other items normal phenomenon. 3. Gallbladder disease: extrahepatic bile duct obstruction, intrahepatic cholestasis, initial biliary cirrhosis and other diseases, due to bile duct obstruction resulting in bile excretion obstacles, there may be total bile acid elevation while other items of liver function is normal. If the total bile acid is elevated while other liver function items are normal, further examination of liver and gallbladder ultrasound, hepatitis virus antigen and antibody test is needed to find out the cause.